No. Some 4x4 tile mfrs ship them in sheets and the webbing keeps the proper spacing during installation (just as it does with smaller or patterned tiles). Be sure to check for a pattern by spreading out a bunch in a square (I suggest at least 3’x3’) so you get a good look at how they match or relate to each other. If not, you run the risk of noticing too late, or worse having a visitor (like your father in law) point it out to you after the job is done.