The fact is that we won't intentionally change our physiology.

We'll go there and our bodies will adapt.

It'll probably kill most of us really young but we'll spend thousands of years using every trick in the book to keep our bodies functioning normally until those of us who can't adapt as well fail to reproduce.

We don't understand gene expression well enough to do a better job of altering it than 3.5 billion years of evolution.

Whales once lived on land and looked like wolves, Europans will view us the same way whales look at wolves today.

The solutions our bodies come up with to adapt to the environment will be unexpected and far better than anything we could plan, for the low low cost of millions of dead people.