Research can only go so far in the social sciences. There is no definitive answer. Having said that, looking at the rust belt it probably one of the best recent examples of mass replacement via uncompetitive labor markets https://en.wikipedia.org/wiki/Rust_Belt

The answer seems to be that yes, the invisible hand won't magically create new jobs in a free market, government investment into propping up new industries is necessary.

The question is can government keep up with the coming replacement.