It's not even close. These people will go knowing they can't come back. You're only talking about getting lost. Space involves far more pernicious dangers. It's a 9 month trip just to get there, and then years before you eventually die or a method of return travel arrives. We don't know how Mars gravity or radiation will affect the human body long-term. You can't go outside ever again. Can't see a blue sky or watch a bird fly. In modern terms, you'll never again access the internet. It's possible that minor injuries are likely to be death sentences. And the money involved is astronomical compared to building wooden ships. Essentially, the psychological stress will be unlike anything humans have encountered to date.

I strongly suggest looking at astrophysicists' discussions about life on Mars and travel to Mars for a more complete understanding of the possibilities and challenges.

There's also a separate option that for profit corporations will undoubtedly exploit: the singularity is predicted for 2029, when machine general intelligence will surpass human intelligence. Subsequent advances in robotics will likely result in fully humanoid robots capable of self maintenance and repair by the 2040s or 2050s, which eliminates the need for food and water and places unrestricted timelines on operations. Human settlements are likely to be built by said robots because not a ton of people will be up for one way trips and the cost of sending robots is significantly lower.