I'm gonna go with the big science thing that is guaranteed to change the life of every future human and current earth resident: the ongoing destruction of our planet. In short terms, climate change, mass extinction, plastics and forever chemicals, plus the still real threat of global nuclear war. Sure fusion might power the light and heat in 50 years (we are nowhere near actually using fusion power), and AI might be able to design better systems or solutions. The coming years will deliver major changes to human societies, but it's unlikely they are going to be for the better.