psychsafetyalliance OP t1_itsjf9m wrote
Reply to comment by cnaasct in We are Dax Jackson and Ally Lee of Psychedelic Safety Alliance. We are here to provide scientific, no-BS adult harm reduction education around psychedelics. by psychsafetyalliance
If you're on an SSRI and you don't respond to mushrooms on them, we're not aware of anything you can take to change that, short of doing a controlled taper off your SSRIS and being off them for a little while (which, to be clear, we are not recommending and should be done under the supervision of a medical professional).
SSSRIs are the main pharmacological agent we're aware of that will inhibit your response to psilocybin, but that doesn't mean they're not out there.
As far as boosting the effects of psilocybin, the one thing we know of is thelemon tek method, which you can also do a quick, jankey version of by just throwing some lemon into your mushoom tea.
psychsafetyalliance OP t1_itsjney wrote
However, as far as we know, taking SSRIs with psilocybin does not cause serotonin syndrome. Taking way too much MDMA does, as can taking the supplement 5-HTP while on MDMA.
deviltamer t1_itw7pof wrote
I know you guys put disclaimers in most of the posts and say as far as we know in this one but it's still short in caution,imo
TL:DR There's not enough evidence if psilocybin can cause serotonin syndrome with SSRIs
But no doubt the risk is dose, person AND SSRI drug dependent.
Almost all popular psychedelics target serotogenic pathways including psilocybin.
SSRIs increase serotonin synaptic availability and so do psilocybin but you're right some SSRIs will block psilocybin effects but others can produce dangerous multiplicative effects.
Please donot mix brain altering chemicals especially unsupervised. Permanent neural disability can and does happen albeit rarely.
More likely is you'll have a traumatic experience and be adrift from a tool that could have really helped you clinically.
Viewing a single comment thread. View all comments