Somebody said pick an airline and stick to them for the loyalty rewards. I'll take it a step farther and get a credit card that has rewards points you can use with that airline. You can get access to lounges in most large airports which will make your layovers infinitely more enjoyable.

Is your work sending you on these flights? If so they should be reimbursing you for first/business class flights with early boarding. You get on the plane before most of the people lining up, always have overhead space, larger seats with more legroom.

TSA pre check is a must. In fact look into Clear. You can skip to the front of the security line as well. Global entry if it's international flights.