I live in downtown closer to Market St and have noticed that Jackson Street and Middlesex St east of South St is generally fine. The rowdy-ness around the Transitional Living Center is far enough away from the Jackson/Appleton lofts that I wouldn't say it's a significant factor to the safety of the area. Not saying the area is perfect, rather it's about as safe as anywhere in downtown. I experience way more unhinged folks on Merrimack St than around Jackson St.