Hi Manchester, UK. Yes, sometimes there is some confusion. At my work we've received a CV from someone in Manchester, UK not realizing they were applying out of country. I've also done some community work where complaints from Manchester, UK residents were sent to organizations here in the US.

When I'm traveling out of the US and people ask me where I live, I tell them north of Boston. That's usually the nearest location that folks know globally. If I'm somewhere else in the US, I say I'm from New Hampshire, sometimes I have to tell them that's in the northeast of the US bordering Canada.

Manchester is the largest city north of the Boston metro area - that includes the US states of Maine, New Hampshire and Vermont. So, yes, it's probably the most well-known Manchester - certainly in those 3 states and New England. I'm no sure if it's the most well-known in the US. There's a big music festival in Tennessee called Bonnaroo. That is held in Manchester, Tennessee. That alone might make that Manchester more well-known to other US Manchester's. However, NH has held the first presidential primary in the US for the last 100 years, giving our Manchester quite a bit of limelight every 4 years.