I can speak to the layout somewhat vs a standard 75. I've been using a Microsoft Sculpt Ergonomic for about eight years. That's about as close to a split as I've ever had. Went to the K6 and noticed within about a day the inside of my wrists had sharp pains that go away quickly when I go back to the sculpt ergo. I anticipate a similar pain free experience with the Q11. That will be an important part that I'll mention in the review.