I'm a queer Pennsyltuckian! (from the south central part of the state)

Central PA in a nutshell: DON'T

The anti-LGBTQ bigtory has really ramped up in the past couple years and I feel less safe than I did 10 years ago. I would feel even less safe if I were trans.

There's a few towns/cities in the region that may be fine themselves, but the surrounding communities are very unfriendly and the county as a whole may be hostile (example: Lancaster city itself is way better than Lancaster county as a whole). Local queer communities are organizing in these areas, but if you can avoid it and have no roots there, it's best to not go there.

If it's doable for you, I would try to stay within the Philly suburbs/southeast PA or Pittsburgh.

For Philly suburbs you're probably fine as long as you're within around an hour of Philly (I'm not from the area tho so this is just a general perception). The problem is these areas are extremely expensive.

Pittsburgh and some of its inner suburbs are also fine and are way less expensive. You definitely need to do your research if you go outside of Pittsburgh itself since it does not take long to get into deep red territory, but Pittsburgh itself is pretty progressive.

I don't know much about the Lehigh Valley or Erie but I've heard that Erie is pretty friendly?