As someone who very much dislikes opioids (qualitatively), but might like to partake in a nonzero amount of other recreational substances, not worrying about inadvertently nodding off and dying would be nice.

Obviously this is gross oversimplification, and there are tons of precautions one can take against accidentally ingesting anything laced with fentanyl, but I have no use for opioids; I would gladly pay some pharmaceutical company hundreds of dollars to permanently remove any recreational/therapeutic potential from opioids in exchange for immunity from incidental opioid overdose. Is it possible that I would regret that decision later if I got into a really nasty car accident, for example? Yes, and I'm willing to live with that, and I don't even have tattoos.

I see this as a win, even if it isn't pulling addicts up out of the gutters and fixing their problems.