Submitted by n8saces t3_10533dv in UpliftingNews
Comments
godnrop t1_j3aoclb wrote
Statins?
_SonOfPear_ t1_j3bxy3s wrote
Yeah going to need to see some evidence on this one.
palpablescalpel t1_j3cn0it wrote
Any risk of statins is far outweighed by the benefit they provide. And I haven't seen anything confirming the risk proposed by that commenter.
I-goes-to-eleven t1_j3f2lrs wrote
Nope
OnundTreefoot t1_j3ayumf wrote
The plaques are not the problem - been proven for 20 years that you can remove all the soluble and insoluble beta amyloid and there is no clinical benefit but because beta amyloid chains integrate into blood vessels, there is cranial hemorrhaging. This mAb is no different and should not have been approved, IMO.
palpablescalpel t1_j3a765l wrote
Is this anything like the last one, which is wildly expensive and no insurance company will cover it because it wasn't proven to be effective?
Read the article:
>It has shown “potential” as an Alzheimer’s disease treatment by appearing to slow progression, according to Phase 3 trial results, but it has raised safety concerns due to its association with certain serious adverse events, including brain swelling and bleeding.
>If (continued) trials confirm that the drug provides a clinical benefit, the FDA could grant traditional approval. But if the confirmatory trial does not show benefit, the FDA has the regulatory procedures that could lead to taking the drug off the market.
Sounds like it just showed potential for removing amyloid plaques, which are still not firmly shown to be the primary cause of the cognitive decline.
About 14% serious adverse effect rate vs 11% in placebo. The brain issues had notably higher frequency
>in people who had a gene called APOE4, which can raise the risk of Alzheimer’s disease or other dementias.
Which stinks (and is poorly written. The gene is APOE and APOE4 is just one variety of APOE).
Consistent_Dream_740 t1_j3dco1i wrote
I had a friend who was tirelessly working on Alzheimer's. She slept in her lab and barely ever left. She had received a large sum of money to further her research, but the pressure was too much. Unfortunately she lost her life due to deep sadness a couple of years ago. This news brings me joy because I hope it would bring her some too.
FreshTongue t1_j3auggw wrote
Alzheimer's is a frightening thought. Crazy to think how your memories and brain deceive you. This is great news.
n8saces OP t1_j4o5jkp wrote
It truly is.
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chemicalrefugee t1_j38mihs wrote
good thing here (probably) as we need help with this. it's a plague.
now if only they could get docs to stop prescribing medications that are known to cause brain damage and or dementia (statins, lyrica, neurontin, etc).