More accurately, the aircraft is flying to the part of Kentucky nearest Cincinnati. The airport code CVG stands for Covington, Kentucky, though the airport itself is called Cincinnati/Northern Kentucky International Airport.

Kentucky is a very popular base for air cargo as CVG and SDF (Louisville) have lots of land for warehouses and are centrally located. Tennessee and Indiana are also quite popular. For shipments between North America and Asia, Alaska, especially Anchorage, is actually the ideal cargo hub location as it allows for better fuel economy (aircraft don't need to reduce cargo capacity in order to carry more fuel for longer flights) and the federal government waives certain cabotage laws, thus allowing foreign airlines to switch cargo between aircraft for the domestic US portion.