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bionic_human t1_j7bg75a wrote

Given that the autoantibody response starts months or years prior to the development of clinical symptoms, it’s plausible that SARS-CoV2 infection accelerated the presentation of symptoms among people who were already autoantibody-positive yet asymptomatic. That would account for the initial spike in diagnoses, which appeared to correlate due to the myopic nature of the initial studies, but once that initial wave came through, later studies would be expected to find no overall increase in incidence.



open_reading_frame t1_j7ed696 wrote

Would this acceleration also occur with coronaviruses that cause the common cold or is this specific to sars-cov2 or the 2009 H1n1 virus?


bionic_human t1_j7fg4kq wrote

I would expect it to occur with any virus that causes metabolic disruption. I haven’t seen any statistical analysis on timing of new diagnoses, but many T1s report getting diagnosed around holidays, during which virus transmission (even asymptomatic) naturally spikes.

I’d imagine to even begin to get a feel for it, you’d need a huge sample size and accurate medical record coding to mine for. KP and other large health systems would be the most likely to have the necessary data, but someone would have to see enough value in the research/potential results to actually fund the analysis, even if you had access to the data.