I think it's important to note that prions take years to show symptoms when mentioning no known cases.

I also wonder if people who are less likely to send their hunted meat in for testing are also less likely to receive diagnosis in case of an infection for various social, financial and personal reasons? To clarify, I'm talking about people who for various reasons refuse to see doctors and when they finally encounter one might be misdiagnosed due to lack of prolonged contact or seeing limited number of doctors who might miss the symptoms due to the rarity and lack of experience.