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Iron_Garuda t1_jefsh2f wrote

Reply to comment by ilovemybrownies in What is known about pain enhancement? For instance, are there drugs that are the opposite of analgesics? If so, what are they and how do they work with neurons/neurotransmitters? by DollyPartWithOn

Are you aware if it’s a reversible phenomenon?

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ilovemybrownies t1_jefu3on wrote

Thankfully if you stop using long enough it does seem to go away for many people. Some studies suggest it's reversible in the sense that your pain receptors may "reset" their tolerance after roughly 5-6 months of abstinence from the drug. Sometimes doctors have success just rotating opioids in their patient's med schedule and using other pain meds in-between.

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