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barbzilla1 t1_jeh2h6l wrote

Reply to comment by AAA515 in What is known about pain enhancement? For instance, are there drugs that are the opposite of analgesics? If so, what are they and how do they work with neurons/neurotransmitters? by DollyPartWithOn

They set the temperature of a scientific hotplate to the level painful but not physically damaging to lab mice, then administer a combo of whatever drug they are testing and a control/placebo to various mice, they then place said mice in said hotplate and time the pain reaction. The mice usually get used for between a week and a month then are either dissected or disposed of.

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