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Thick-Molasses-8960 t1_jchlpvl wrote

No. There is no significant "tolerance" built for pain medication such as aspirin, acetaminophen(tylenol), or anitinflammatories. Especially not on a biophysical level the way opioid medications develop tolerance.

If you feel the effect of aspirin is reduced over time, it's more likely that 1) your pain is worse or 2) you use it often enough you are no longer "impressed" by the same level of pain relief

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Dave30954 t1_jcifykd wrote

Replying to 52ndstreet (#2,249,764)

Physical tolerance is different from mental tolerance, genius.

Physical tolerance is like if you get drunk enough, it takes more to get you drunk. Like the same level of drunkness literally gets physically harder because your body gets better at breaking down the poison.

Mental tolerance is like you get the same level of drunk but get bored of it. Like the pain relief is the same amount, you just want more now. Like you want total pain relief, which simply isn't possible unless you're completely healthy to begin with.

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Derragon t1_jciuky3 wrote

Replying to ronmfnjeremy (#2,249,026)

A tolerance in this case would suggest that the body is no longer responding to the medicine and pain relief no longer being provided by it. In regards to impressed it's more that it worked the same amount and you just don't go "Wow!" anymore - it worked as you already knew it would.

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Rosevkiet t1_jcivkmq wrote

Replying to ronmfnjeremy (#2,249,026)

I listened to a really interesting Ezra Klein podcast about chronic pain treatment and the importance of taking a whole body approach. The guest’s main point is that pain originates with an injury or illness, but the patient’s experience of it can be influenced by their day to day life, mental health, supportive care, and levels of stress. I wish I could express it better, because when I write this out it sounds like I’m saying “it’s all in your head!”, but that is definitely not what she was saying. But it would explain someone having reduced relief from pain medication when they don’t have a biochemical reason to do so.

TLDR Pain is a complex sensation and what people experience is hard to understand.

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LightlyButteredCats t1_jcjr4xc wrote

Replying to Rosevkiet (#2,250,663)

Makes sense. I usually get hungry about 5 hours after breakfast, but if I’m busy at work and moving around a lot it doesn’t really bother me much. But if I’m just sitting alone in front of a computer hunger is the only thing I’m thinking about.

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arettker t1_jckky0f wrote

Replying to StaffMental6035 (#2,251,895)

When used properly there’s likely little to no negative long term effects

Taken in high doses you have liver issues with Tylenol and stomach/GI bleeding risk with Ibuprofen/aspirin

Low doses of aspirin reduce your risk of heart attack/stroke when taken daily and increase your risk of GI bleed

Some studies have shown a link between long term Tylenol use and early mortality, increased risk of heart attack, etc. however all these were observational studies with many confounding variables (for example someone who takes Tylenol daily is likely less healthy than someone who doesn’t need Tylenol daily so they may have a higher risk of death at baseline)

Basically if you don’t have any comorbidities or other risk factors and follow the directions on the package you’ll be fine and not experience any damages to your body. If you already have severe kidney or liver disease you probably should be more cautious

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