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Xambia t1_irmledn wrote

Reply to comment by dan_dares in Could CRISPR transform a mouse stem cell to a human stem cell? by scrooch

Not to mention the relative expression of these new proteins would likely be off compared to those in a normal human cell. Having the new DNA is one thing, but having the correct epigenetic factors governing gene expression is another issue.

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CrateDane t1_irntu0p wrote

To be fair, CRISPR can also be used for epigenetic editing. But doing that across, if not the entire genome then at least all of the genes, is... a challenge.

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