Cultural-Twist7546 t1_irrxkgg wrote on October 10, 2022 at 4:06 PM

Does a person with a genetic MTHFR variant have an increased risk of thrombosis? What is the criteria to be called inherited thrombophilia?

WorldThrombosisDay t1_irrz60w wrote on October 10, 2022 at 4:17 PM

The MTHFR variant is not related to increased risk of venous thromboembolism (VTE). There are six tests that are definitely associated with increased risk of venous thromboembolism and should be on any inherited thrombophilia testing.

They are: measuring functional antithrombin levels, protein C levels, protein S levels, looking for Prothrombin 22 10, measuring fibrinogen levels, and lastly doing a test for Factor V Leiden.