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Grogfoot t1_iu50dpc wrote

Reply to comment by ELI-PGY5 in Does the cerebral spinal fluid of people with Alzheimer's have a notably different pH from 'normal' people's? by wrhollin

"Fluids" is pretty broad, and would include things such as urine, which can be quite variable. But, OP and the thread is referring to fluids that would likely be those continuous with blood and would definitely not vary by an entire pH unit!

Typical pH values of blood are ~7.3. A blood pH less than 6.8 wouldn't even be incompatible with life let alone "normal range".

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ELI-PGY5 t1_iu5ei09 wrote

Sorry, it’s 2am and I misread. The guy I was responding to is too high not too low. Normal range for blood pH is .1 unit, I would disagree that pH varies by 0.2 in normal conditions, 7.2 to 7.4 is a pretty massive difference as you presumably know.

But that’s largely irrelevant to my point, which is that pH is not so stable that it can’t be used for diagnostic purposes. It’s just that it’s not used for the diagnostic purpose that the OP asked about, and the behaviour of tau proteins etc as noted in the reference doesn’t lead me to think that it is likely to be.

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