Xilon-Diguus t1_isjd1lp wrote on October 16, 2022 at 12:59 PM

Reply to comment by Alwayssunnyinarizona in Are proteins used inside the nucleus of eukaryotic cells synthesised outside the nucleus (like other proteins) and transported back inside the nucleus? I had things like histones and transcription factors in mind when I thought of this question. Many thanks by scuba_dooby_doo

It is also worth pointing out that we do this on purpose and can modify the proteins we insert into genomes to contain an NLS (Nuclear Localization Sequence).

Alwayssunnyinarizona t1_isjlsrx wrote on October 16, 2022 at 2:12 PM

A protein I work with has a plasma membrane localization sequence, but we delete it because it's unnecessary for our studies 👍

There are a whole host of these signal peptides routing proteins all over the cell: https://en.wikipedia.org/wiki/Signal_peptide