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Jonh_McCourt t1_iuvt606 wrote

Reply to comment by danby in Would a person who is allergic to domestic cats also be allergic to big cats? by housemuncher

I'd argue that the d1 homologous protein in big cats works differently, the reaction would be much more severe even fatal when coming in contact.

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danby t1_iuw8lt1 wrote

> the reaction would be much more severe even fatal when coming in contact.

Why? As the paper shows, in Table 2, patient Fel D 1 specific IgE and IgG4 bind significantly less strongly (often by an order of magnitutde less) to the big cat proteins. I'll admit it's been a fair while since I studied much immunology but my understanding is less binding of Igs is associated with less immune system activation and less strong immunological responses.

(though of course a person could later go on to develop a specific allergy to a big cat fel d1 homologue)

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zsero1138 t1_iux9uj4 wrote

coming into contact with a big cat can be fatal, even ignoring the allergy aspect of it

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GeriatricZergling t1_iuxi5ex wrote

"Autopsy notes: subject showed signs of nasal congestion, hives, disemboweling, and itchy eyes."

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