Viewing a single comment thread. View all comments

danby t1_iuw8lt1 wrote

Reply to comment by Jonh_McCourt in Would a person who is allergic to domestic cats also be allergic to big cats? by housemuncher

> the reaction would be much more severe even fatal when coming in contact.

Why? As the paper shows, in Table 2, patient Fel D 1 specific IgE and IgG4 bind significantly less strongly (often by an order of magnitutde less) to the big cat proteins. I'll admit it's been a fair while since I studied much immunology but my understanding is less binding of Igs is associated with less immune system activation and less strong immunological responses.

(though of course a person could later go on to develop a specific allergy to a big cat fel d1 homologue)

5

zsero1138 t1_iux9uj4 wrote

coming into contact with a big cat can be fatal, even ignoring the allergy aspect of it

5

GeriatricZergling t1_iuxi5ex wrote

"Autopsy notes: subject showed signs of nasal congestion, hives, disemboweling, and itchy eyes."

10