Nope. Since the dawn of time no gene mutations have ever occurred and been passed on that would make human or human ancestors better at fighting any sort of disease. Just kidding. Ha. What comes to mind is the recessive form of the gene that causes sickle cell anemia—gives immunity (not sure if full, but maybe partial) to malaria. I’m sure there’s at least thousands of other examples known to man, and at least millions, billions, or an unfathomable amount that actually would have had to occur throughout history.