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F0xFiree t1_ivyf7et wrote

Uh hi I actually have turners syndrome. Mosaic turners to be more specific. This means some of my genes are missing an X chromosome and some have an xxxy thing. I had two ovaries. My left was abnormal; it was described as streaked, flat and generally not formed and was probably nonfunctional. It was removed during the c section delivery of my youngest child. My right one however works just fine. Proof for that is that I’ve conceived naturally and have two kids to show for it.

Due to my genetic make up though, having ovaries when having an xxxy chromosome make up gives me a much higher chance of developing tumors so my remaining ovary is being plucked out next week. Hope this info from someone’s personal experience helps!

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silvandeus t1_ivytq5t wrote

Forgive me but I am curious, what are the odds of passing on such chromosomal content to your offspring? Would only those zygotes with expected chromosomal content be viable?

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Sicon3 t1_ivywybl wrote

Turner syndrome is caused by an abnormality in the sperm or egg cell itself hence it occurs naturally in the population. Turner syndrome usually causes infertility but as in the above individuals case it doesn't always cause infertility. A person with turners syndrome is (to what knowledge I have and can find) not significantly more likely to produce abnormal eggs than anyone else.

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F0xFiree t1_ivyz2yx wrote

Bingo. Also, plenty of women who have turners syndrome don’t even find out they have it until later in life when they’re ready to have children. They seek medical help when they have trouble conceiving, and this is what usually leads to the discovery of turners in the first place.

My situation was not entirely unrelated to the described scenario above, however I was actually already newly pregnant with my second child and my prenatal blood work had come back with some concerning markers that eventually led to a diagnosis of turners syndrome in myself. I would likely have never found out had I not gotten pregnant again. I’m pretty short (which is one big side effect of having turners) but women being short runs in my family on both sides already and the type of testing that had started all of this for me wasn’t routine when I had been expecting my first child. I could have probably never questioned it or other things tied to my diagnosis. Life’s funny like that I guess.

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Cannie_Flippington t1_ivz1ird wrote

Internet says it's not directly inherited. Which makes sense since it's a mutation during meiosis so the resulting gamete would be XX, XY, X-, or Y-. In order to be inhereted the germ-line cells would all have to be XX or XY in someone with three chromosomes and would be incomplete in someone who had only partial XX or XY and they would likely have pretty severe fertility issues. At least 50% of all first trimester miscarriages are due to chromosomal instability, and being XXY, X, X+, Y, Y+, or XYY all qualifies. For contrast, the number of chromosomally abnormal living people is about .5%. If all the germ line cells of someone who was chromosomally abnormal were also abnormal... that's not great odds for having kids.

Male XYY aren't sterile, but male XXY usually are - but this is because of their testes not working properly, not necessarily what they would produce if they had functional ones.

Most Turner's women are sterile for the same reason - their ovaries just don't work properly. OP lucked out that the ordinary redundancy of the second ovary yielded a functional one and is a perfect example that their gametes are not effected by their own abnormality.

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F0xFiree t1_ivz57ul wrote

>Most Turner's women are sterile for the same reason - their ovaries just don't work properly. OP lucked out that the ordinary redundancy of the second ovary yielded a functional one and is a perfect example that their gametes are not effected by their own abnormality.

Yes exactly! I was called a “medical marvel” by my genetic counselor for conceiving not one but two children with little to no difficulty. Something about my specific mosaic make up with my turners really let me “get off easy” when it comes to some of the physical side effects of having it. I have no heart liver or kidney issues, no trouble having kids, etc. I’m just short as hell unfortunately hahaha

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Revolutionary-Run306 t1_ivzzbe2 wrote

How tall r u?

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F0xFiree t1_iw0b2ab wrote

Average adult height for a woman with turners is something like 4’8”. One of the few instances of my life where I can say I’m above average.

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