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wintrmt3 t1_ix31wxy wrote

Reply to comment by say-something-nice in How does the body know which allele is dominant and which is recessive? by JannickL

> , the % of guanisine-Cytosine within the gene

How does this affect expression?

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say-something-nice t1_ix3l7xz wrote

Sorry my mistake guanine- cytosine

Higher GC content has been shown to affect polymerase efficiency in DNA elongation. It's not 100% understood why because it has been shown not to be due to the more stable bonds of GC and the better annealing which we exploit in primer design.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463026/

https://www.pnas.org/doi/10.1073/pnas.1518976113

https://pubmed.ncbi.nlm.nih.gov/20203083/

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