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lambertb t1_ix5ui9t wrote

Reply to comment by radioactivemagic in Do NSAIDs reduce neuroinflammation? by One-Garden-1294

It’s more than just emerging. There is an FDA mandated warning on the label about increased risk of stroke and heart attack, in addition to bleeding, and kidney damage. NSAIDS are not generally safe drugs.

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Duckboy_Flaccidpus t1_ix5zeq1 wrote

All this seems to fly in the face of something like Bayer aspirin that says it helps to reduce heart attacks and can be prescribed a small dose daily to aid in continued blood flow.

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15MinuteUpload t1_ix6bo7m wrote

Aspirin has a different mechanism compared to other NSAIDs and does in fact have well-studied benefit in heart disease protection and clot risk. That being said, that benefit is likely less than previously believed due to more recent studies and evidence and it does not come without risks, but it certainly exists.

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lambertb t1_ix67fdw wrote

It’s complicated. Aspirin is an NSAID, but not Al NSAIDS are the same with respect to adverse effects. Aspirin has cardiac benefits because it’s an anticoagulant. The same basic effect is why NSAIDS can cause bleeding strokes. I can’t explain all the mechanisms. I just know it to be true.

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jaldihaldi t1_ix6ojvo wrote

Though ibuprofen might cause green in high blood pressure patients?

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55peasants t1_ix6y51o wrote

Asprin inhibts COX-1 more than COX-2, last time I read up on it, this was the theory on the difference on cardiovascular safety

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EmilyU1F984 t1_ix7kzvu wrote

Why did anyone even think that? Coxibes cause cardiovascular risk through Cox2 inhibition. All nsaids so that to some degree, or they would be useless. So all NSAID’s have cardiovascular risks associated with them, proportional to dose and duration.

Meaning they are generally save if used according to OTC ‚rules‘ over here: no more than 3 days for fever. No more than 4 days for pain, and not for frequent pain/fever without a physicians recommendation/prescription.

Selling 500 count bottles obviously doesn‘t help making them not look like candy.

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lambertb t1_ix7w4t1 wrote

Agreed that they are generally safe when used as directed. But they are contraindicated in anyone with kidney disease, and probably a poor choice for anyone with cardiac risk, bleeding risk, or stroke risk, which in the US, is a lot of people. Sadly, there are no safe pain meds. It’s all risk/benefit calculation.

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holy-reddit-batman t1_ix87zqa wrote

Holy hell. That's the recommended length of use for each of those? I've been taking naproxin probably 6 times a week for as long as I can remember. I have serious arthritis and widespread pain.

Would a person know if they were having internal bleeding? My GI is screwed up from some other conditions. Now I'm wondering if any of that is going on.

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EmilyU1F984 t1_ix8la31 wrote

Not necessarily, any GP can test for hidden blood in stool though. Black stool is indicative of a bleed higher up in the GI tract anything bright and Tim’s likely hamprrhoids.

(And on the reverse black or blood coloured vomit)

You need to talk to your physician though, daily naproxen might be the best treatment option even with all the risks, But there‘s also other treatment options for arthritis, especially if you are using OTC painkillers daily.

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