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unsigned1138 t1_ix6h732 wrote

Reply to comment by Dr_Vanc_Zosyn in Do NSAIDs reduce neuroinflammation? by One-Garden-1294

So you mind if I interject here, being specific for neuralgia’s. Trigeminal, Geniculate, occipital, glossopharyngeal, etc.

I think I know the answer that medication with anti-convulsive properties are more effective, but the question stands. Are there anti-inflammatory properties to NSAIDS that may help?

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Dr_Vanc_Zosyn t1_ix6kex3 wrote

That would make sense to me. Trigeminal neuralgia at least is caused by direct compression of the trigeminal nerve root, which certainly causes some degree of inflammation. Inflammation is probably a minor contributor though; demyelination seems to be the main cause of pain in that condition. NSAIDs can treat the pain and inflammation there. Anticonvulsants are more effective because they directly modulate the firing of those nerve fibers and prevent them from generating a pain signal in the first place.

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