There are studies out there that mention how people taking ibuprofen for a long period of time for reasons like arthritis tend to have lower rates of Parkinson’s/Alzheimer’s, and neuroinflammation seems to play a part in those diseases.

That’s as far as my knowledge goes though. Would it be advisable to take NSAIDS for “no reason” to prevent neuroinflammation? I don’t know. There’s definitely side effects.