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EmilyU1F984 t1_ix7kzvu wrote

Reply to comment by lambertb in Do NSAIDs reduce neuroinflammation? by One-Garden-1294

Why did anyone even think that? Coxibes cause cardiovascular risk through Cox2 inhibition. All nsaids so that to some degree, or they would be useless. So all NSAID’s have cardiovascular risks associated with them, proportional to dose and duration.

Meaning they are generally save if used according to OTC ‚rules‘ over here: no more than 3 days for fever. No more than 4 days for pain, and not for frequent pain/fever without a physicians recommendation/prescription.

Selling 500 count bottles obviously doesn‘t help making them not look like candy.

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lambertb t1_ix7w4t1 wrote

Agreed that they are generally safe when used as directed. But they are contraindicated in anyone with kidney disease, and probably a poor choice for anyone with cardiac risk, bleeding risk, or stroke risk, which in the US, is a lot of people. Sadly, there are no safe pain meds. It’s all risk/benefit calculation.

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holy-reddit-batman t1_ix87zqa wrote

Holy hell. That's the recommended length of use for each of those? I've been taking naproxin probably 6 times a week for as long as I can remember. I have serious arthritis and widespread pain.

Would a person know if they were having internal bleeding? My GI is screwed up from some other conditions. Now I'm wondering if any of that is going on.

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EmilyU1F984 t1_ix8la31 wrote

Not necessarily, any GP can test for hidden blood in stool though. Black stool is indicative of a bleed higher up in the GI tract anything bright and Tim’s likely hamprrhoids.

(And on the reverse black or blood coloured vomit)

You need to talk to your physician though, daily naproxen might be the best treatment option even with all the risks, But there‘s also other treatment options for arthritis, especially if you are using OTC painkillers daily.

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