Naproxen has cox2 inhibitory effects, if thus increases cardiovascular health risks. And like any nsaid it can cause chronic interstitial nephritis (kidney damage) in long term and or high dose use.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869646/ for the kidney specific part.

This is true for aspirin, ibuprofen, naproxen, Diclofenac etc.