Submitted by One-Garden-1294 t3_z0cmd1 in askscience
BZRich t1_ix8jmo8 wrote
Reply to comment by Igggg in Do NSAIDs reduce neuroinflammation? by One-Garden-1294
This was the initial finding suggesting this in a really small group: McGeer, P. L., et al. (1990). Lancet 335(8696): 1037.
Here is the Rotterdam Study: in t' Veld, B. A., et al. (2001) N Engl J Med 345(21): 1515-1521.
This showed a 5 fold reduction for people who took NSAIDs for more than 2 years. See Table 3 relative risk = 0.2. This caused a lot of excitement.
Alas John Breitner's RCTs say otherwise: ADAPT Research Group. (2008). Arch Neurol 65(7): 896-905.
Meyer, P. F., et al. (2019). Neurology 92(18): e2070-e2080
Igggg t1_ixat4qm wrote
Thank you for the citations!
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