Viewing a single comment thread. View all comments

hiv_mind t1_iys33w1 wrote

Reply to comment by supervisord in Does treatment with daily antihistamines have an effect on the severity of other allergies like food or medication allergies? by KingZarkon

Sort of. It's a "lesser-sedating" antihistamine, compared with first generation. But it's one of the most sedating of its generation. Loratadine is better, and fexofenadine better still (ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1118461/).

With "lesser-sedating" antihistamines, it's just a less favourable concentration gradient to get it through the BBB - so higher doses absolutely can get central effect.

12