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floridawhiteguy t1_iz0gvo8 wrote

https://pubmed.ncbi.nlm.nih.gov/26502571/

https://pubmed.ncbi.nlm.nih.gov/21706814/

Long stories short: Ethanol can both potentiate and suppress agonist-induced Ca(2+)-dependent vasoconstriction.

IOW: Low levels appear to help calcium in enhancing blood flow, while high levels seem to strip calcium levels causing all sorts of ill effects.

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[deleted] t1_iz13j69 wrote

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Nianms t1_iz144wu wrote

Animals use lactic acid fermentation for anaerobic respiration as opposed to ethanol fermentation. So we don’t ever produce any ethanol to deal with, only lactic acid.

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Ajenthavoc t1_iz1avca wrote

That's true in muscles, but plenty of fermentation happens in the gastrointestinal system with approximately 3g of etoh that the body has to deal with daily.

see page 24

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Nianms t1_iz2lopu wrote

Huh that’s pretty interesting. Thanks for the paper!

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TWeaKoR t1_iz15d7r wrote

Damn, suddenly I've remembered a whole topic that I should have already known. Thank you for the correction.

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[deleted] t1_iz0qccx wrote

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[deleted] t1_iz0tbwh wrote

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uglychiccwhosthicc t1_iz1cpch wrote

It’s because of the receptors in your brain the molecules attach to. Each neurotransmitter has a different physiological effect when it’s released. Ethanol binds to GABA receptors in the brain which is an inhibitory neurotransmitter. Kinda works in a similar way to an anxiolytic (an anti-anxiety medication). They bind to the GABA receptors and that, in turn, decreases nerve transmission, which decreases neuronal excitability. One of the physiological occurrences is vasodilation

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OneOfUsOneOfUsGooble t1_iz1unxs wrote

"The action of alcohol on the vasculature is variable according to its concentration and the kind of blood vessel. High concentrations of alcohol constrict most blood vessels. This vasoconstriction depends on calcium ions and is inhibited by calcium channel blockers. Alcohol also acts to augment the vasoconstriction caused by catecholamines and vasopressin and inhibits endothelium-dependent vasodilation. It has been suggested that endothelin and nitric oxide are involved in alcohol-induced vasoconstriction. . . . On the other hand, low concentrations of alcohol usually dilate blood vessels. This effect also seems to be mediated by calcium ions and endothelium-derived nitric oxide. It has been shown that low doses of alcohol increase the release of nitric oxide and augment endothelium-dependent vasodilation."

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uummbbraa t1_iz1kq47 wrote

The effects of alcohol on blood vessels can vary depending on the amount of alcohol consumed. A small amount of alcohol can cause vasodilation, which is the widening of blood vessels, while a large amount of alcohol can cause vasoconstriction, which is the narrowing of blood vessels.

The reason for this is that alcohol interacts with the walls of the blood vessels in different ways at different concentrations. At low concentrations, alcohol can cause the blood vessels to relax and become wider, which allows more blood to flow through them. This can cause the face and skin to become flushed and warm, and it can also lower blood pressure.

At high concentrations, alcohol can have the opposite effect on the blood vessels. It can cause the blood vessels to constrict and become narrower, which reduces blood flow. This can lead to decreased blood pressure, which can cause dizziness and lightheadedness. Vasoconstriction can also cause the skin to become pale and cold, and it can lead to reduced oxygen and nutrient delivery to the tissues.

The effects of alcohol on blood vessels depend on the concentration of alcohol in the blood. Small amounts of alcohol can cause vasodilation, while large amounts can cause vasoconstriction.

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SuperSkyDude t1_iz2ad38 wrote

> vasoconstriction Wouldn't vasoconstriction cause higher blood pressure while vasodilation would cause lower blood pressure?

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