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dangelem t1_j1qn79p wrote

Well blood types A, B, and AB produce mainly IgM antibodies which cannot cross the placenta so this is really only an issue when the mother is blood type O, which produces mostly IgG antibodies that can in fact cross the placenta. However I think the percentage of developing HDN is very low, something like 4%, and when it happens it is mild. Something about the baby’s antigens not being properly developed so the antibodies cannot properly bind to destroy the blood cells.

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onewilybobkat t1_j1t1gjp wrote

Just to add, look up James Anderson. He has an antigen that saved a ton of babies from being attacked by their mothers blood because it was incompatible. Complications can arise to do conflicting blood types.

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