Submitted by dante662 t3_10ay32m in askscience
Ok-Arm-362 t1_j48uhy1 wrote
You are actually asking 2 questions. The frequency of dosing for effect, and maximum dosing to avoid problems. The labeling for the latter is not based solely on pharmacokinetic data. Rather, a mix of data, opinion and (at least in the US) the FDA's assumption that all users are dumb as a bag of hammers.
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