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seanmorris t1_j4zaifl wrote

Reply to comment by firstfrontiers in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher

>Any large muscle group will do

This is not always true, even if it applies to covid vaxes. Muscles vary greatly in their receptor expression.

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boooooooooo_cowboys t1_j505s4p wrote

You’re not trying to get your vaccine into the muscle cells themselves. All the action happens in the draining lymph nodes.

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firstfrontiers t1_j5061lt wrote

To my understanding you're trying to get it absorbed into the bloodstream, which is why you aim for muscle which is highly vascular tissue

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yellow_edge t1_j509412 wrote

You don't want it in the bloodstream, and they're even supposed to check that they don't accidentally enter a vein by aspirating before administering the vaccine dose.

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OnTheClockShits t1_j509ujj wrote

That’s out of date practice. Some people may teach to aspirate but it’s unnecessary.

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firstfrontiers t1_j505f7w wrote

Interesting, I didn't know about this! Do you have any more detail on that?

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volyund t1_j510adm wrote

Seriously?! I had no idea! Is there an article I can read on that? I've taken basic immunology, but that wasn't covered.

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