im_thatoneguy t1_j5164ex wrote
Reply to comment by Silverjeyjey44 in Is there any difference in efficacy when a vaccine is administered somewhere other than the upper arm (e.g. on the foot)? by MercurioLeCher
One reason recently is illustrated by the rare cardiac side effects from the various Covid vaccines. There's evidence to suggest that the virus' spike proteins themselves can cause damage to cells even just as non-functional fragments. So a sore and inflamed arm muscle from your deltoid muscle cells reacting to the spike proteins is fine. But if your heart gets hit by a bunch of Covid Spike proteins and gets inflamed that may be what's causing myocarditis even though they aren't being infected by a virus.
YouAreGenuinelyDumb t1_j51ituv wrote
Do the spike proteins from the mRNA typically remain local in deltoid muscle or do they distribute in significant quantity around the body?
im_thatoneguy t1_j51pb6h wrote
I believe that's still a point of interest without a definitive answer. There are studies which showthere is circulating spike protein. There are studies which show similar levels of S Protein circulation between vaccination and infection. But there are also studies showing that infection causes higher rates of myocarditis. Both could be true (Spike Protein could be one cause of myocarditis and the higher rates of myocarditis in infected patients being due to compounding causes in addition to the circulating S protein.) But I don't think there is even a definitive answer yet on whether the spike proteins are exclusively responsible for all of the vaccine induced myocarditis.
YouAreGenuinelyDumb t1_j51wjrb wrote
Thank you for the links and answer!
I wonder if the LNP’s may be behind some of the cases. There was a possible vaccine-induced myocarditis in the Novavax trial, which are LNPs with recombinant protein S. Although the the fact that it contains protein S may be confounding.
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