Each person is different, but I happen to know that for a healthy 6’5”, 200lb 27yr old male, who was a moderate opiate addict, a dose of 25 10mg pills (250 mg hydrocodone) taken orally of hydrocodone did not cause overdose. Their were ill effects, but no loss of consciousness and no hospitalization. Again, each person’s chemistry is going to be different, but that did happen.