Submitted by AskScienceModerator t3_10px8sa in askscience
AdministrationLimp71 t1_j6mq0fp wrote
hi! curious layperson here: how do you physically equip the bacteria with something unfamiliar to them?… do you ask nicely? 😁
intengineering t1_j6ob4pf wrote
Hi! Oh, I would love that, that could make life MUCH easier if bacteria could listen to the voice of reason! But no, we do it pretty scientifically!
In our work, the synthetic components were integrated onto Escherichia coli. We use a strain of E. coli that allows for one-step binding of such nanoparticles through a physical complex known as “biotin-streptavidin complex”. Basically, these bacteria have “biotin” protein that binds to the “streptavidin” protein that is on the surface of the nanomaterials we use here. We mix them together under certain conditions (temperature, shaking, and the type of liquid media are all very important), et voilà, your bacterial biohybrid microswimmers are ready.
Thanks for the Q.
All the best,
/birgül
AdministrationLimp71 t1_j6oenxh wrote
thank you!!!
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