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blp9 t1_j5uhmq0 wrote

Reply to comment by [deleted] in What determines whether we can create a vaccine for an illness or not? by ShelfordPrefect

>(also during all years of mrna development it was never tested on humans)

This is a table with at least a dozen completed human clinical studies for mRNA cancer treatments prior to 2017.

While this is a table of mRNA infectious disease trials, with at least 3 of them completed. Also all prior to 2017.

This is from a journal article published in 2018.

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LSeww t1_j5untbx wrote

Most of them are I/II phases studies (dozens to low hundred participants), only two at phase III, of which one is terminated (no desirable effects) another is expected to end in 2023. A decent amount of them were not even completed in 2019. So no, nothing was tested on humans at the time they decided to use if for covid. "Tested" means completed phase 3.

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blp9 t1_j5uv2dz wrote

That is a much better point than "it was never tested on humans".

Is your position that the Pfizer and Moderna Phase 3 trials were flawed in some way and therefore don't count?

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LSeww t1_j5uw7zb wrote

The point is: they chose a technology never (successfully) tested on humans for a “warp speed” vaccine development. Of course their phase 3 trials don’t count.

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