I have walked this route many times day and night and am like 5’3” and femme. I’ve gotten cat-called/harassed verbally but that’s similar to like… everywhere I’ve walked in this city and others. Obviously I can’t make a blanket statement that you will be 100% fine and nothing will ever happen to you, but I truly don’t think there’s a heightened risk along N Charles or even St Paul. I would just say don’t wear over-the-ear headphones and be alert and aware of your surroundings, but that really goes for walking anywhere at night I think. You can also carry a knife (I do) or pepper spray, but make sure you know how to use any tool you carry before doing so.