I used to do Reservoir Hill to DC. I’d take the bus down north Ave until they redid the bus system, then I had the option of that, or the slightly longer bus more confident bus from directly where I was staying to like a block away from Penn. I’d recommend that neighborhood, you’re near a park, the zoo, good areas to walk and a lovely neighborhood cafe called Dovecote. And if you have a car, you’re not from from either Penn or West Baltimore stops. Don’t take the Camden line, focus only on the Penn, it has more trains, is faster, and runs weekends as well. Especially consider Station north as well. Good luck