I used to make the drive from Baltimore to Bethesda regularly. Honestly 95 is usually pretty free-flowing in the mornings in my experience with some minor backups as you’re leaving Baltimore, but it clears pretty well after the 695 interchange. The DC beltway is gonna be where you really hit traffic so that’s what I’d be looking at and figuring out what time you’ll arrive there. In the evenings, expect beltway traffic, then some traffic around the 100 & 32 interchanges, and some more going into downtown Baltimore. I’d say your average commute will be 45min-1hr on a decent day, depending where in Baltimore you live (this is assuming you’ll be by 95).

My biggest piece of advice would be avoiding BW Parkway/295 as much as you can…as in, don’t take it unless an accident has happened on 95. My GPS has tried to take me on that road ever since I moved to Maryland years ago and it’s always a shit show of traffic and hold ups. And lord forbid you get one slow person in the left lane who’s stubborn, because traffic will get held up for miles. It is almost never faster to take 295 unless you’re going into downtown DC, and you’re not. There is almost never not traffic around numerous interchanges (495, 197, 32), unlike 95 which really only gets traffic at rush hour.