This I can get behind, in spite of my earlier snarky comment. I've lived car-free in Baltimore for 12 years. Choosing a neighborhood carefully is important (though sounds like you'll still have a car). Biggest hassle is groceries- Baltimore has a real challenge in access to groceries, so look where the grocery stores are in order to start looking for housing- some popular neighborhoods have no grocery access, so you end up still basically car dependent. It's great to be walkable to groceries, and even if you still have a car you'll want a decent transit line or two nearby, you can download the Transit app to see what your transit options are near where you are looking. Walkable neighborhoods with grocery stores and some transit access could include Hampden, Charles Village, Mt. Vernon/Midtown, Station North, Downtown, Locus Point (parts of Fed Hill as well, groceries being the issue here); parts of Fells (again, groceries are a problem); Canton.

Charles village/ waverly is a good spot. Maybe some parts of Hamilton/lauraville though it’s more of a suburban feel with larger lots and homes, so slightly less walkable. Hampden, maybe Bolton hill or station north though not as familiar with walkable amenities/ shops etc over there

i lived without a car for five years here, and it's more or less okay if you are a strong bike rider. things aren't close enough to walk everywhere you will want to go, and public transit is only sporadically convenient, doesn't run very late and is more designed for commuting than getting around town

in terms of safety, just use the same advice as you would for any city; don't walk around by yourself late at night and avoid closed off areas with no people. don't go to unfamiliar areas before understanding them and the neighborhoods

do some research about what you want to live close to most and find an area to look for a place that is close by. if you want to know more about that neighborhood, ask here