To me the book is more an artistic work. One extensive rabbit hole is the footnotes. Careful reading reveals at least one of them that references an obscure but real person, a scholar, who wrote a real work of scholarship that is referenced in the book.

Others have purportedly found embedded messages in the words written in the book since it was written.

All of the phenomena within and around the the House of Leaves transform it into a concept piece that threatens to be endless as it snarls back in and around itself.