I like Oryx and Crake, just re-read it myself -- but I also really enjoyed One Hundred Years of Solitude in high school. I really enjoyed the magical realism, and the fact that it's an epic family saga covering several generations. Be warned though, at least one character marries a child, which I found weird even at the time and looking back as an adult, was super gross. However I would still read the book again. It's a deep world to get lost in.