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SsurebreC t1_ja5k0if wrote

Our cells continue to make copies all the time. Whenever a copy has a problem - a mutation - then the cell usually kills itself. Sometimes it doesn't and the mutation lives on. Some of these aren't a problem but some are. For instance, cells can grow too quickly while being mutated and that's called cancer.

Getting old is basically our body not being good at copying cells anymore where a lot more errors are introduced to the point where our body eventually shuts down. This isn't a bad ELI5 of aging.

We're not good at solving the problem though. There's some research in stem cells but that might be more like applying duct tape to torn clothes rather than making clothes repair themselves or last longer.

Think of it as making a copy of a copy. We can create printers that last longer (healthy diet, etc) but in the long run, it's still a machine and machines break.

There is another special type of cell that's required for life: neurons. Unlike other cells, neurons don't divide. So right before you're born, you have the most neurons you'll ever have in your life and you'll continue to lose them as you age. Again, stem cells could help here via transplants which is an artificial solution at best.

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Enzo-chan OP t1_ja5nv0e wrote

Fascinating, can you tell me more please?

I read about epigenetics and how David Sinclair and his team supposedly reversed the clock of some of mice's cells, I don't study the field so I don't understand anything at all, lol.

Also there are Aubrey de Grey claiming to use senolytics, NAD+ injections, and even Telomerase could work to treat the Hayflick limit, extending health and lifespan.

Are David Sinclair/Aubrey de Grey dishonests scams? I mean, can their techniques be replicated by the scientific community? I don't want to believe any treatment until they're actually proven to work.

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SsurebreC t1_ja5ovcv wrote

I'm not an expert but I bet there are issues of scale here. We're men, not mice, after all.

There's another issue which is discussed in a scifi series called Altered Carbon. Presuming we could have a very long lifespan, imagine what that would do to people as far as careers and retirement planning. It would be a massive disaster.

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Enzo-chan OP t1_ja5pkec wrote

A very long lifespan would be a headache, read somewhere years ago that our brain can only support 300 years in memory if kept healthy. If that is true I think we'd start forgetting things after 200 years. 300 years we would start sense the world aa if we were plants I suppose.

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